Diabetes Mellitus (DM) poses a significant health challenge globally, with a rising prevalence that demands effective management strategies. This paper presents the crucial role of gamma glutamyl transferase (GGT) as a biomarker in Type 2 DM, focusing on its potential implications for early diagnosis and management. It is one of the leading causes of morbidity and mortality worldwide and poses serious medical, socioeconomic, and rehabilitation problems.The study highlights the increasing burden of diabetes in India, emphasizing the importance of early detection in combating the disease’s multiorgan complications. By examining the correlation between GGT levels and Type 2 DM, this study sheds light on the potential of GGT as a valuable biomarker for monitoring and preventing complications associated with the condition. This presentation underscores the significance of GGT in mediating extracellular glutathione transport and maintaining intracellular antioxidant defenses, thereby linking oxidative stress to the pathophysiology of diabetes.Through a detailed analysis of GGT levels in diabetic patients compared with healthy controls, this study underscores the significance of GGT as a potential indicator of disease progression and risk assessment.The findings suggest that GGT measurement could serve as a valuable tool in the early diagnosis and management of Type 2 DM, offering insights into the underlying mechanisms and potential therapeutic interventions.Overall, this paper presentation aims to contribute to the growing body of knowledge on the role of biomarkers in diabetes management, with a specific focus on the utility of GGT in enhancing clinical outcomes and improving patient care.