Primary hyperparathyroidism (PHPT), a common endocrine disease characterized by hypercalcemia and elevated or inadequately normal levels of parathyroid hormone, is diagnosed based on biochemical analyses. Even "asymptomatic" patients may have skeletal abnormalities (evident on imaging; e.g., DXA), and subclinical manifestations may include osteoporosis and hypercalciuria, as well as clinically asymptomatic vertebral fractures and nephrolithiasis. The diagnosis of normocalcemic PHPT can be made after the elimination of the secondary causes of hyperparathyroidism; however, data on its natural course and the corresponding criteria and response to surgery are limited. Parathyroidectomy  performed by an experienced surgeon is recommended for patients with symptomatic disease or subclinical damage to target organs, since no drug treatment method eliminates hypercalcemia and the skeletal and renal consequences of  PHPT.

Larisa Bugova defended her PhD thesis in 2013. He has been working as an associate professor at the Department of Faculty Therapy at Kabardino-Balkarian State University since 2006. He is the author of 85 scientific articles, 2 monographs, 15 brochures on the pathology of the endocrine system, published in peer-reviewed journals. Her  publication h-index is 10. She is a member of the European Association for the Study of Diabetes (EASD).