Background: Diabetes Mellitus(DM) is a major public health problem which is rapidly escalating globally as well as in India affecting all age & sex group. Dreaded micro-vascular complications of  DM include diabetic retinopthy and nephropathy.In parallel to increase in prevalence of DM and its complications, several reports of serum 25(OH) VitD deficiency have been documented in India.

Objective: To establish the association between proteinuria and presence as well as severity of diabetic retinopathy & their relation with VitD deficiency.

Materials & Methods: The current study was conducted in a tertiary care teaching hospital in Kolkata of India, approved by the institutional Research & Ethics Committee. In this present study,107 Type 2 diabetic patients of 40 yrs of age & above were selected. Direct Ophthalmoscopy(Heine β - 200) was used for detection of Diabetic Retinopthy(DR)and grading of  DR . Venous blood for FBS,PPBS, HbA1C  and 25(OH)VitD level estimtion was taken aseptically. Urinary protein was tested by Dip stick method.

Results & Conclusion: Results were analysed by using SPSS version 20. Kolmogorov-Smirnov, Spiro-Wilk test, Chi square test, Fischer Exact test,Man Whitney U & Kruscal Wallis test were used in statistical analysis as appropriate. Results showed that Proteinuria was present in highest percentage of total patients. Our data are not normally distributed. There was statistically significant association between proteinuria and presence as well as severity of Diabetic retinopathy. In our study, the presence of proteinuria is significantly associated with deficiency of serum VitD level in diabetics without retinopathy group, patients with ‘Severe NPDR’ & total patients i.e patients with or without DR. Deficient VitD status is significantly associated with severity of Diabetic Retinopthy in presence of proteinuria.