
Raydeh Al Khani
Damascus University, SyriaTitle: Utility of IHC for Hormone Secretion in Pituitary Adenomas for the Prediction of Outcomes
Abstract
Various types of hormones, prehormonal substances and transcription factors are detected in
pituitary adenomas.
Immunohistochemical study have an increasing importance in pituitary adenomas for the
accurate diagnosis and the prediction of clinical outcomes of these adenomas.
Monohormonal secretion in pituitary adenomas is frequent; notably prolactin secretion.
Bihormonal secretion is well known, classically GH-PRL and FSH-LH.
Other combinations
of bihormonal secretion are reported; they are sometimes underestimated.
Plurihormonal secretion in pituitary adenomas is usually under estimated; it is in most cases
subclinical.
Demonstration of hormones, transcription factors for functional differentiation and
proliferation index have an important role in the classification, prediction and treatment of
these adenomas, as the demonstration of neuroendocrine differentiation.
IHC is frequently not performed and the accurate classification and prognosis of these
adenomas remains obscure.
Biography
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