Rada Citra SaputraMuhammadiyah University of Surakarta, Indonesia
Title: The differences in efficacy of vildagliptin as a single drug with vildagliptin as a combination with metformin in type ii diabetes mellitus: A systematic review
Background: In America, the prevalence of diabetes mellitus about 8.6% or 21 million adults in 2016. In Indonesia, the prevalence of diabetes mellitus has increased 2% from 2013-2018
for people aged more than 15 years. Vildagliptin is an oral antihyperglycemic drug class DPP4 inhibitor which has been approved for use in type 2 diabetes mellitus. However, the benefits
and risks of vildagliptin may be different for monotherapy and combination especially with metformin. This systematic review explain the efficacy of vildagliptin as monotherapy and vildagliptin in combination with metformin in type 2 diabetes patients. These findings can be used to develop treatment recommendations for type 2 diabetes mellitus.
Methods: Data collection techniques for systematic review using Pubmed and Sciencedirect for terms related to efficacy vildagliptin as single drug and efficacy vildagliptin as combination
with metformin in HbA1c, FPG, risk hypoglycemia and weightloss of T2DM. The journals matched with restriction criteria and PICO. The quality of journals is tested using GRADE
Results: Journal searches found 741 journals, 8 of which were eligible for systematic review with high quality journal by GRADE method. The review of 8 journals found that vildagliptin as combination with metformin has good efficacy and can reduce HbA1c (8.1±0.6% to 6.9±0.1%), FPG (141±15mg/dl to 106±4mg/dl), and lower risk of hypoglycemia and weightloss about 4.67±5.8kg for lowdose combination and 4.29±6.7kg for highdose combination.
Conclusion: Vildagliptin is more effective in combination with metformin in T2DM patients than vildalgiptin as single drug.
I am Rada Citra Saputra, i was born in Wonogiri, July 31st 1998. I have graduated as Bachelor of Medicine in Faculty of Medicine, University of Muhammadiyah Surakarta at 2021. Now, i am a 2nd years medical student clerkship as Co-assisstant at Karanganyar Regency General Hospital.