4th GLOBAL MEETING ON DIABETES AND ENDOCRINOLOGY
November 18-19, 2024 | Bangkok, Thailand
Theme: Modern medical research and application on diabetic condition & endocrinology function
Ian Lake
Gloucestershire, UKTitle: Nutritional ketosis is well-tolerated, even in type 1 diabetes: the ZeroFive100 Project; a proof-of-concept study
Abstract
The objective of this study was to test the feasibility
of exercising over a 5-day period while fasting, in those with and without type
1 diabetes mellitus (T1DM).
Eight individuals, ages 29--62 years, two with T1DM,
walked/ran around 20 miles per day for five consecutive days while only
consuming water. All eight individuals completed the project with no physical
injuries or problems with diabetes control. The blood glucose levels ranged
from less than 3 mmol/l to 7 mmol/l in those without T1D, and less than 3
mmol/l to 9 mmol/l in those with T1D. The continuous glucose traces in those
with T1D showed little variability in glucose levels. The participants without
T1D had no symptoms from blood glucose under 3 mmol/l. Ketone levels ranged
from 0.3 to 7.5 and the ketone profiles for those with T1D were indistinguishable
from the ketone profiles in those without T1D. The respiratory quotient was
overwhelmingly in the fat-burning range. All
but one person was keto-adapted ahead of the event. Prolonged fasting did
neither lead to hunger nor did it negatively affect mood, which, if anything,
was enhanced in most individuals.
This proof of concept study has found that in
keto-adapted individuals, with or without T1DM, prolonged exercise for 5 days
while in nutritional ketosis was feasible, and well tolerated. Nutritional ketosis is not a risk factor for
diabetic ketoacidosis; consumption of sugar for energy is not required for
distances of up to 100 miles in keto-adapted people; people who inject insulin
do not necessarily need to consume carbohydrates unless rescuing a
hypoglycaemic attack.
An identical project has been
completed by non-diabetic individuals in South Africa with similar results.
Biography
Ian Lake have been a GP for 35 years and work in Gloucestershire. He is concentrating the rest of my career around promoting knowledge of keto diets through my website www.type1keto.com. There is a healthcare professionals study course suitable for CPD and information for people with Type 1 themselves. He have a degree in Medical Cell Biology and Biochemistry from Liverpool University and qualified as a doctor in 1985 from Southampton University.
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