Background: Aegle marmelos is a medicinal plant reported to possess multiple therapeutic properties, including potential anti-inflammatory effects in chronic subclinical inflammation.

Objective: This study aimed to investigate the anti-inflammatory effect of Aegle marmelos unripe fruit pulp in patients with type 2 diabetes mellitus (T2DM).

Methodology: An unblinded, crossover clinical trial was conducted at the Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh, from July 2010 to June 2011. The study evaluated the effect of Aegle marmelos unripe fruit pulp on chronic subclinical inflammation in T2DM patients, measured by high-sensitivity C-reactive protein (hsCRP). The intervention was administered during two periods (days 0–21 and days 28–49) with a 7-day washout period in between. Data from both phases were pooled, and baseline hsCRP values were compared with endpoint values.

Results: Mean hsCRP levels did not show significant differences between the intervention and control periods at any time point. Additionally, no significant difference was observed between baseline and endpoint hsCRP levels. Overall, Aegle marmelos supplementation had no significant effect on hsCRP levels in the study population.

Conclusion: The findings indicate that Aegle marmelos unripe fruit pulp does not significantly alter chronic subclinical inflammatory status, as measured by hsCRP, in patients with T2DM.

Dr. Murshida Aziz is an experienced biochemist and medical educator with over 18 years of professional experience. She is currently an Assistant Professor in the Department of Biochemistry at Ibrahim Medical College, Dhaka, where she has been serving since 2014. She completed her MBBS from Dhaka Medical College and earned an MPhil in Biochemistry from BIRDEM. Her academic roles include teaching undergraduate medical students, conducting practical and research activities, and participating in professional examinations as an examiner and evaluator. Dr. Aziz has received formal training in medical education and scientific writing and is a life member of BSMB and BSP.