Prader-Willi syndrome(PWS) is a rare multisystem genetic disorder & one of the syndromic causes of childhood obesity. It is characterized by learning difficulties & behavioral challenges with subsequent multiple endocrine and multisystem involvement. Congenital leptin deficiency is also a very rare disorder that causes early-onset obesity with hormonal & metabolic disturbances. Here we describe a case of an 11-year-old girl. Who presented to us with uncontrolled blood sugar, excessive weight gain with behavioral disturbance, who is diagnosed as a case of Prader-Willi syndrome(PWS) with congenital leptin deficiency, Type 2 Diabetes mellitus, Hypothyroidism, Hypertension, Obstructive sleep apnea(OSA). The main objective of this case report is to describe barriers to glycemic control & lifestyle modification challenges & implement optimal management in such a case.

Javed Imran has completed his M.D (endocrinology&Metabolism) from BIRDEM, DHAKA. He is currently working as an M.O in the National Institute of Neuro Sciences & Hospital, Dhaka. He is a member of the Bangladesh Endocrine Society. He has multiple publications