Saibal Chakravorty, Metro Multispeciality Hospital, India
Title : ACE2 Receptors Expression in Health and Infections
ACE2 (Angiotensin Converting Enzyme 2) is an integral membrane glycoprotein that is expressed in various organs of the body such as kidney, lungs, heart and endothelium. It shares structural similarity with ACE and is not inhibited by ACE inhibitors. ACE2 degrades Angiotensin II (Ang II) to form Angiotensin 1-7 which opposes the action of Ang II. Augmentation of ACE2 expression can lead to beneficial effects providing some organ protection and has a potential role in managing health and various diseases. ACE2, the receptor for SARS-CoV has been seen to express in human airway epithelia and lung parenchyma as assessed by immunofluorescence staining. Augmentation of ACE2 expression by recombinant ACE2 or via agonists like Xanthenone and Resorcinolphthalein may prove beneficial as a treatment in a wide range of ailments.
Dr Saibal Chakravorty ( MD. (Med), FRCP, FICP, FIACM, Diploma in Diabetes (UK)) is working as a senior consultant and unit head in the Department of Internal Medicine, Diabetology and Critical care, Metro Multispeciality Hospital, Noida, India for last 20 years. He has keen academic interest and is currently the Editor-in-chief of Journal Of Internal Medicine Of India and member of Editorial board/ peer reviewer of Journal Of Clinical Diabetes And Obesity (Pragma Journals). He has many international & national publications and has written several chapters in books of national repute.