Lisette Leal Curí, Havana University of Medical Sciences, Cuba
Title : Iodine Nutrition, Function, and Volume of the Thyroid Gland in Cuban Healthy Pregnant Women
Iodine deficiency during pregnancy damages maternal-fetal health. Purpose: The purpose of this study was to evaluate urinary iodine concentrations (UICs) in healthy pregnant women from the Plaza Municipality at different stages of pregnancy, trying to correlate such levels with thyroid function parameters as well as with thyroid volume. Patients and Methods: This cross-sectional study included 101 pregnant women from Plaza Municipality, in La Habana, Cuba, from September 2015 to August 2016. The variables analyzed were maternal and gestational age, trimester, skin color, number of children, smoking habit, UIC, thyrotropin, total and free thyroid hormones, thyroglobulin, and thyroid volume. The UIC was compared with the rest of the mentioned variables. Results: The UIC median in the total cohort was 153.5 ?g/L (interquartile range 85.58- 221.42) and 43.6% had values lower than 150 ?g /L. In women with more advanced pregnancies, UIC was lower (first trimester 182.8 ?g / L, second 160.2 ?g /L, and third 143 ?g/L). 91% of women with insufficient intake had a UIC between 50 and 149.9 ?g / L. There were no statistically significant differences with clinical variables. Positive correlation of UIC with free T4 and T3 was demonstrated. Thyroid function parameters did not show statistically significant differences according to iodine. The mean thyroid volume was 6.17± 1.7 mL and did not correlate with UIC.
Conclusions: Iodine intake was adequate in the total cohort although bordering the lower limit and was insufficient in the third trimester. UIC was not related to clinical variables, thyroid function, or thyroid volume
Lisette Leal Curí graduated as a specialist in Endocrinology in 2011 at the National Institute of Endocrinology and has a Master's degree in Public Nutrition from the Institute of Nutrition and Food Hygiene of Cuba since 2017. She has led several research projects related to thyroid diseases, mainly in pregnant women. She is a professor and researcher at the Medical University of Havana. She has published scientific articles in several medical journals. She is a member of different endocrinology societies and is on the editorial board of some scientific journals.