
Keita Kaly
University Hospital Center of the Point G, MaliTitle: Panorama of Autoimmune and Autoinflammatory Diseases in Internal Medicine at the University Hospital Center (UHC) of the Point G
Abstract
Autoimmune diseases result largely from a
deregulation of the specific immune system and
are subdivided into two groups, systemic
autoimmune disease of which the target antigen is
distributed in different organs or tissues of the
body (example, systemic lupus erythematosus,
rheumatoid arthritis) and organ-specific
autoimmune disease of which the target antigen is
located in a tissue or a cell (example, autoimmune
type 1 diabetes, Graves' disease). As for autoinflammatory diseases, they are due to an
abnormality of innate immune system. Thus, two
groups are distinguished, the monogenic autoinflammatory disease whose the mutation is
carried by a gene of innate immunity (example,
familial mediterranean fever, IgD deficiency) and
polygenic auto-inflammatory disease whose
several genes are involved in the dysregulation of
innate immunity, subdivided also into two groups:
“systemic” polygenic auto-inflammatory disease
characterized by systemic impairement in their
usual clinical form (sarcoidosis, Still's disease)
and “organ-specific” polygenic auto-inflammatory
diseases by organ-specific impairement in their
typical clinical form (spondyloarthropathy,
Crohn's disease). These nosological entities have
in common the chronic inflammatory processes
but their clinical and biological expressions are
extremely variable. It is therefore important to
analyze, in perspective, these large heterogeneous
groups of inflammatory diseases as a whole in
order to better understand epidemiological,
immunogenetical, environmental,
pathophysiological and clinical disparities, thus
favoring research of therapeutic targets and new
approaches for the preventive medicine. In the
first instance, to appreciate these epidemiological
and clinical disparities, we conducted a
descriptive study with a retrospective data
collection between 2005 and 2019 by providing
the panorama of autoimmune and autoinflammatory diseases in the Internal Medicine
Department. During the study period, 331 cases of
autoimmune diseases and autoinflammatory
diseases including 07 cases of associations were
noted from 317 medical records, of which there
were 291 cases of autoimmune diseases and 40
cases of autoinflammatory diseases.
Biography
Kaly Keita has completed his Doctorate Degree in
general medicine at the Faculty of Medicine,
Pharmacy and Odontostomatology of Bamako in
2011 and his Specialized Study Diploma in the
field of internal medicine in 2020. He is a writer,
single author of a medical book and author of a
medical book with multiple authors. Author or coauthor of more than thirtieth scientific articles and
more than twentieth scientific communications, he
is reviewer in some reputed medical journals.