
Justyna Flotynska
Poznan University of Medical Sciences, PolandTitle: The higher NDUFS8 protein serum concentration is associated with higher insulin sensitivity among people with T1DM and might reflects better mitochondrial turnover
Abstract
The aim of the study was to evaluate NADH
dehydrogenase [ubiquinone] iron-sulfur protein 8
(NDUFS8) serum concentration as a marker of
Complex I and the relationship with insulin
resistance in T1DM. Participants were adults with
T1DM, recruited during 1 year (2018-2019).
NDUFS8 protein serum concentration was
measured using the ELISA test. Insulin resistance
was evaluated with indirect marker estimated
glucose disposal rate (eGDR). The group was
divided on the base of median value of eGDR
(higher eGDR – better insulin sensitive). The study
group consisted of 12 women and 24 men. Medians
of eGDR and NDUFS8 protein concentration were
7.6 (5.58-8.99) mg/kg/min and 2.25 (0.72-3.81)
ng/ml, respectively. The group with higher insulin
sensitivity had higher NDUFS8 protein serum
concentration, lower WHR, BMI and they were
younger. A negative correlation was observed
between NDUFS8 protein serum concentration and
WHR (rs=-0.35,p=0.03), whereas a positive
correlation was observed between NDUFS8
protein serum concentration and eGDR
(rs=0.43,p=0.008). Multivariate linear regression
confirmed a significant association between insulin
sensitivity and better mitochondrial function
(beta=0.54,p=0.003), independent of age, duration
of diabetes and smoking. Higher NDUFS8 protein
serum concentration, which reflects better
mitochondrial turnover, is associated with higher
insulin sensitivity among adults with T1DM.
Biography
Justyna Floty?ska is a PhD student at the Medical
University of Pozna?. She is a doctor at the
Department of Internal Medicine and Diabetology.
She has many publications. She is a member of
Diabetes Poland. Currently, she is implementing a
research grant and deals with physical exercise
among patients with type 1 diabetes