Ayman Riyadh Abdel Hameed
Zagazig University, EgyptTitle: Prevalence, risk factors and impact of proteinuria-associated hypomagnesemia in chronic kidney disease patients: cross-sectional study
Abstract
Hypomagnesemia is a predictor of progression and mortality
of chronic kidney disease (CKD) patients. However, limited data is available
about the prevalence, kidney-related risk factors of hypomagnesemia in the CKD
patients. We aimed to investigate the prevalence and risk factors of low serum
magnesium level associated with proteinuria and its impact on CKD patients.
This Cross-sectional study enrolling 100 CKD patients with
different stages according to estimated glomerular filtration rate (eGFR),
divided into 2 groups (proteinuric and non- proteinuric) in the period from
February 2020 to August 2020.
Results: The number of participants in this study was
100 subjects, 50 patients were proteinuric, 50 patients had no
proteinuria. The study participants' serum magnesium levels ranged from 1.2 to
2.7 mg/dL. 14 (28%) of proteinuric individuals had a serum magnesium level of
less than 1.8 mg/dL. Urine albumin creatinine ratio (UACR) was significantly
higher in hypomagnesemic patients (2071 mg/g vs. 812 mg/g, P<0.001), hypomagnesemic patients had
significantly higher CRP (48 mg/L vs. 12 mg/L, P<0.001), their mean
haemoglobin levels were much lower as well (10.4 g/dL vs. 10.91 g/dL, P= 0.044). Serum magnesium level showed
negative correlation with UACR (r=?0.504, P<0.001),
parathyroid hormone (r=?0.276 ,
P=0.005) and CRP (r=?0.505, P<0.001).
Conclusions: Hypomagnesemia is a frequent electrolyte
disorder in patients with CKD. Hypomagnesemia is
independently associated with Proteinuria. Hypomagnesemia is a risk factor of
inflammation, anemia and hyperparathyroidism in pre-dialysis CKD population.
Biography
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