Track: Genetics of Diabetes

Session Overview

Genetic Basis of Type 1 and Type 2 Diabetes: Type 1 diabetes is strongly linked to immune-related genes, while type 2 diabetes involves multiple genes affecting insulin secretion and insulin resistance. Genetic variations influence disease risk and progression. Understanding these factors helps explain individual susceptibility.

Monogenic Diabetes and Rare Genetic Syndromes: Monogenic diabetes results from mutations in a single gene affecting insulin production or function. These rare forms often present early in life and are frequently misdiagnosed. Accurate genetic diagnosis allows targeted and more effective treatment.

Gene–Environment Interactions: Genetic predisposition interacts with lifestyle and environmental factors such as diet, obesity, and physical activity. These interactions influence disease onset and severity. Recognizing this relationship supports preventive and lifestyle-based interventions.

Role of Epigenetics in Diabetes Development: Epigenetic changes alter gene expression without modifying DNA sequences. Factors like nutrition, stress, and intrauterine environment can influence epigenetic regulation. These mechanisms contribute to diabetes risk and disease progression.

Genetic Testing and Clinical Applications: Genetic testing aids in diagnosis, risk assessment, and personalized treatment planning. It is especially valuable in identifying monogenic diabetes and guiding therapy choices. Clinical application of genetic data improves precision in diabetes care.

6th Global Meeting on Diabetes and Endocrinology

Track: Genetics of Diabetes

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