Shagazatova B.Kh & Akhmedova F.Sh, Tashkent Medical Academy,department of internal diseases, Uzbekistan
Title : Condition of carbohydrate lipid metabolism in patients with chronic viral hepatitis C
The aim of the study was to evaluate the clinical significance of insulin resistance on the parameters of carbohydrate-lipid metabolism in patients with chronic hepatitis C.
Material and methods.
The study included 41 patients with CHC who were in the clinic of the Republican Scientific and Practical Medical Center of Virology of the Ministry of Health of the Republic of Uzbekistan.The vast amount of 28 (68.2%) patients with hepatitis C has been identified by screening and only 13 (31.8%) patients were examined specifically due to the presence of clinical laboratory abnormalities. Insulin resistance was detected in 31.7% of patients with CHC. No gender differences were found in the groups of CHC patients with and without IR (p> 0.05), as well as the age of patients (38.2 ± 9.9 and 34.8 ± 8.7 years, p> 0.05) .However among patients with IR, people over 40 years old were more common (48.5% and 26.8%, respectively, p <0.05). There was a direct correlation between the weak strength of the HOME IR index and age (r-0.0186; p <0.05).
According to the results of our study, the most common component of metabolic syndrome (MS), detected in 52.8% of CHC patients, was a decrease in the level of high-density lipoprotein cholesterol (HDL-C). At the same time, in patients with IR, the level of LDL-C was significantly lower than in its absence. A decrease in the level of HDL-C was found in the majority (64.6%) of CHC patients with IR, while in patients without IR in less than half of the cases (43.6%, p <0.05). Hypertriglyceridemia was detected in 9.4% of cases, while significantly more often in patients with IR (21.7%) than in patients without IR (3.7%). In patients with IR, the level of triglycerides (TG) was significantly higher (p <0.05) compared with patients without IR.
1. Insulin resistance was detected in 31.7% of patients with CHC and is characterized by the severity of the clinical picture with a predominance of asthenic syndrome, enlargement and compaction of the liver in comparison with patients without IR.
2. In 2/3 of patients with CHC with insulin resistance, abdominal obesity and a decrease in the level of high-density lipoprotein cholesterol were found, which is significantly more frequent compared to patients without insulin resistance.