Daniela Jakubowicz

, Tel Aviv University, Israel
Title : Meal Timing regulation of Circadian Clock Gene mRNA expression in Type 2 Diabetes.


Glucose metabolism and type 2 diabetes are intimately linked with circadian rhythmicity and rely on transcriptional regulation of the circadian clock genes. These endogenous oscillators regulate the 24-h rhythms of physiological and behavioral processes, sleeping hours, nervous systems, appetite, and metabolism (i.e., insulin sensitivity, ?-cell secretory function, muscular glucose uptake, and hepatic glucose production), to anticipate the recurring feeding-fasting cycles and to optimize metabolic efficiency in the appropriate temporal sequence. The circadian clock is organized hierarchically. The central- coordinating clock is synchronized with the light- dark cycle. In contrast, the peripheral clock genes, which are disseminated in most tissues, are namely entrained by food cues, like the hour of food intake or availability. Disrupted circadian clock rhythmicity is associated with metabolic dysfunction and is essential in the pathogenesis of T2D. Meal timing is a potent synchronizer of the circadian clock. We will focus on research studies in obese and T2D individuals. We will show how meal timing aligned with the circadian clock (i.e., high energy breakfast and reduced dinner) has a synchronizing effect on clock genes expression and a therapeutic effect, improving glycemic control, weight loss, and appetite in T2D.


Professor Daniela Jakubowicz, MD, has completed his specialization in Endocrinology at Columbia University New York and achieved her affiliation as Professor of Medicine at Virginia Commonwealth University, USA. Since 2009 is working at the Diabetes Unit at the Wolfson Medical Center, associated with Tel Aviv University, Israel. Most of Prof. Daniela Jakubowicz, MD, clinical experience and her multiple research publications and manuscripts are focused on the effect of meal timing on circadian rhythms, clock gene expression in obesity, metabolic syndrome, polycystic ovary and T2D